Comparative Gastroenterology Lab

Led by Drs. Anthony Blikslager and Amanda Ziegler, the Comparative Gastroenterology Lab aims to study translational development of gut health using large animal models, primarily pigs. In multidisciplinary collaboration with Drs. Jack Odle, Laurianne Van Landeghem and Scott Magness, the lab is USDA and NIH funded to study intensively the roles of nutritional inputs in the development of a healthy and disease-resistant intestinal microbiome, enteric nervous system, and epithelial barrier. Our ultimate objective is to develop clinical interventions to aid in restoring the mucosal barrier in patients suffering from diseases associated with increased intestinal permeability.

The Comparative Gastroenterology Lab is a member of the Comparative Medicine Institute and the Center for Gastrointestinal Biology and Disease, an NIH-funded Center linking GI researchers at UNC, Duke and NC State, and houses the CGIBD Large Animal Models Core.

Education & Training Opportunities

Our Lab offers graduate training through the Comparative Biomedical Sciences Graduate Program, a multidisciplinary graduate program with faculty who are employing state-of-the-art techniques to address a number of interesting scientific problems in the basic and applied biomedical sciences. The Comparative Biomedical Sciences Graduate Program is offered through the College of Veterinary Medicine at North Carolina State University and confers Master of Science (M.S.) and Doctor of Philosophy (Ph.D.) degrees. In addition, the laboratory participates in the Comparative Medicine and Translational Research Training Program, trains postdoctoral research scholars, and accepts high school, undergraduate and veterinary student scholars.